Which atypical antipsychotic least weight gain?Asked by: Mary Reynolds | Last update: 18 June 2021
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Intermediate to low level of weight gain was observed with aripiprazole and amisulpiride. Ziprasidone caused the least amount of weight gain. A meta-analysis by De Hert et al observed that the newer antipsychotics asenapine, iloperidone, paliperidone and lurasidone caused significant weight gain.View full answer
Likewise, people ask, Which atypical antipsychotic has the least side effects?
Of the available atypical antipsychotics, clozapine and quetiapine have shown the lowest propensity to cause extrapyramidal symptoms.
In this regard, Which antipsychotics cause less weight gain?.
- Aripiprazole (Abilify)
- Asenapine (Saphris)
- Brexipiprazole (Rexulti)
- Haloperidol (Haldol)
- Lurasidone (Latuda)
- Ziprasidone (Geodon)
Also Know, How do you avoid weight gain on antipsychotics?
The main approaches to managing weight with antipsychotics are: Ensure that the risk of weight gain, and other side effects, are considered when choosing an antipsychotic. Wherever possible use drugs with a lower risk of weight gain. Monitor weight and Body Mass Index (BMI) during antipsychotic treatment.
What mood stabilizer does not cause weight gain?
Unlike most mood stabilizers, though, Lamictal is less likely to cause weight gain. In clinical trials, less than 5 percent of those taking Lamictal gained weight.
Topiramate led to substantial weight loss in patients with bipolar disorders in these studies. The efficacy of topiramate as an adjunct treatment in patients with mood disorders has been demonstrated.
The highest weight gain is with olanzapine, followed by clozapine, risperidone and aripiprazole, similar to adult patients. Differences in weight gain have been noted according to the diagnosis. Patients with autism treated with antipsychotics had greater weight gain.
Meta-analysis found that patients receiving standard doses of atypical antipsychotics for 10 weeks gained a mean of 9.79 lb with clozapine, 9.13 lb with olanzapine, 6.42 lb with sertindole, 4.6 lb with risperidone, and 0.09 lb with ziprasidone.
Weight loss may occur once a person stops taking their medication. However, this will depend on the drug in question and the individual. People who stop taking antipsychotics usually see gradual weight loss. Stopping a medication, however, is not always possible, and it can sometimes have serious repercussions.
Abilify is also associated with metabolism problems. This can lead to weight gain and dangerously high blood sugar levels.
There are more than a dozen antidepressant drugs that are popularly prescribed. But only one has been consistently associated with weight loss in studies: bupropion (brand name Wellbutrin).
But after about 11 weeks, those who took Zyprexa had gained 18.7 pounds; Seroquel, 13.4 pounds; Risperdal, 11.7 pounds; and Abilify, 9.7 pounds.
With respect to the incidence of discontinuation, clozapine was the most effective antipsychotic drug, followed by aripiprazole. As with the survival analysis for time to discontinuation, clozapine and aripiprazole were the top ranked.
Research on other kinds of structural brain changes caused by antipsychotic drugs has been negative to date. There is no evidence, for example, that antipsychotic drugs cause any loss of neurons or neurofibrillary tangles such as are found in Alzheimer's disease.
Clozapine and olanzapine have the safest therapeutic effect, while the side effect of neutropenia must be controlled by 3 weekly blood controls. If schizophrenia has remitted and if patients show a good compliance, the adverse effects can be controlled.
Amisulpride was more effective than haloperidol and, if ziprasidone remains unlicensed, represents the most cost-effective atypical antipsychotic drug.
Data from the cohort of 272 antipsychotic-naïve youth demonstrated significant weight gain over the first 3 months of treatment with all SGAs, including aripiprazole: 4.4 kg, 58.4% gaining ≥7% weight; risperidone: 5.3 kg, 64.4% gaining ≥7% weight; quetiapine: 6.1 kg, 55.6% gaining ≥ 7% weight; and olanzapine: 8.5 kg, ...
A meta-analysis of randomized trials conducted between 1955 and 2012 that evaluated efficacy and tolerability of 15 antipsychotics, both first generation antipsychotics (FGA) and SGAs, found that olanzapine, followed by zotepine and clozapine were associated the highest risk for weight gain, followed in descending ...
In patients treated with < 200 mg/day of quetiapine, mean weight gain was 1.54 kg, compared with 4.08 kg for 200 to 399 mg/day, 1.89 kg for 400 to 599 mg/day, and 3.57 kg for >or= 600 mg/day; median weight gain was 0.95 kg, 3.40 kg, 2.00 kg, and 3.34 kg, respectively.