Does spironolactone cause cancer?

Asked by: Jeremy Hill  |  Last update: 18 June 2021
Score: 4.1/5 (39 votes)

Results. There was no evidence of an increased risk of any cancer associated with spironolactone use. Spironolactone use was associated with a significantly lower risk of prostate cancer (hazard ratio 0.69; 95% confidence interval 0.60–0.80, P < 0.001).

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Similarly, it is asked, Does spironolactone increase breast cancer risk?

Hair Loss Drug Spironolactone May Be Safe for Use in Breast Cancer Survivors. WASHINGTON (Sept. 9, 2020) – Spironolactone is not associated with increased risk of female breast cancer recurrence, according to research from the George Washington University (GW) Department of Dermatology.

Keeping this in consideration, How dangerous is spironolactone?. Spironolactone is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you don't take it at all: If you do not take this drug, your blood pressure will stay high. This can lead to a heart attack or stroke.

Secondly, Is Spironolactone safe for long-term use?

30 The authors concluded that long-term use of spironolactone in the treatment of AV appears to be safe. Although some side effects were relatively common, they were usually not troublesome or severe enough to result in cessation of the drug.

Can spironolactone cause ovarian cancer?

Among 2.3 million women (28.5 million person-years), risks of breast, uterus, ovary, and cervix cancers were generally increased about 10-30% in both spironolactone and furosemide users. In the first year of drug exposure, incidences were increased, especially for ovary cancers.

29 related questions found

Does spironolactone increase estrogen?

Spironolactone has been found in some studies to increase levels of estradiol, an estrogen, although many other studies have found no changes in estradiol levels.

Why is spironolactone a hazardous drug?

May cause eye, skin, or respiratory system irritation. Suspected of causing cancer.

Can I take spironolactone for years?

The long-term use of spironolactone in the treatment of acne in women appears to be safe. Side effects, however, are common, although not usually a cause for stopping the drug.

How long can you stay on spironolactone?

How long will I need to take spironolactone before I see an effect? Most women find that their acne starts to improve after about 3 months of treatment. Hair complaints take longer, and treatment usually needs to be continued for up to six months before the benefit can be seen.

Is there an alternative to spironolactone?

Amiloride and triamterene may be used instead of spironolactone. They have a direct effect on the renal tubule, impairing sodium reabsorption in exchange for potassium and hydrogen.

Who should not take spironolactone?

a condition where the adrenal glands produce less hormones called Addison's disease. low amount of sodium in the blood. high levels of potassium in the blood. acute kidney failure.

Do you need to wean off spironolactone?

The reality is that spironolactone only works when you're on it. If you do stop taking it, it's possible that your hormonal acne will come back. "If you go off, then the effect of the body's hormones will go back to what it was before you started," says Dr. Zeichner.

Can spironolactone make you gain weight?

There are concerns that spironolactone can cause weight gain, but there isn't much evidence it does. For example, the package insert for the drug doesn't list weight gain as a side effect. Along with weight gain, many people worry that spironolactone will make their skin look worse when they first start taking it.

Does spironolactone affect breast tissue?

Spironolactone is known to cause more gynecomastia or breast pain (up to 10%) in male patients than eplerenone (up to 0.5%). Unlike eplerenone, spironolactone is known to inhibit free testosterone from binding to androgen receptors in the cytoplasm of breast cells.

Does spironolactone cause breast cancer in men?

However, only two men within the General Practice Research Database had both a diagnosis of breast cancer and a history of exposure to spironolactone, suggesting that an increased risk of male breast cancer with exposure to spironolactone was unlikely, although the small number of cases makes any study infeasible.

Does spironolactone have a black box warning?

There is a black box warning for spironolactone stating that it may increase certain tumors, which has been shown in animal studies, but Dr. Graber notes that the dosage of medication was significantly higher than what is prescribed for women to treat acne.

Does spironolactone affect mood?

Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. In a case series of women with treatment resistant FMS spironolactone was therefore added to their medication, and they were observed for at least 12 months.

Should I drink more water when taking spironolactone?

Be sure to drink adequate water while taking spironolactone. Watch for signs of dehydration, including: excessive thirst.

Can you drink alcohol while taking spironolactone?

Notes for Consumers: It is best to limit your intake of alcohol while taking this drug. Alcohol can increase the risk for low blood pressure and dizziness. If the blood pressure drops too low, you may feel dizzy or faint, in some cases falls or fainting may occur.