Are ttp and itp the same?

Asked by: Jayden Brown  |  Last update: 18 June 2021
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Thrombotic thrombocytopenic purpura (TTP) and idiopathic thrombocytopenic purpura (ITP) are two well recognized syndromes that are characterized by low platelet counts. In contrast, essential thrombocythemia (ET) is a myeloproliferative disease characterized by abnormally high platelet numbers.

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Also, Are platelets low in TTP?

If you have TTP, you'll have a lower than normal number of platelets and red blood cells (anemia).

Also, What is TTP blood disorder?. Thrombotic thrombocytopenic purpura (TTP) is a blood disorder in which platelet clumps form in small blood vessels. This leads to a low platelet count (thrombocytopenia).

Correspondingly, Is TTP an autoimmune disease?

This form or TTP is considered to be an autoimmune disease and is caused when patients develop an antibody against the ADAMTS13 protease leading to low levels of the protease.

What is the condition ITP?

Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a decrease in the number of platelets in the blood. Platelets are cells in the blood that help stop bleeding. A decrease in platelets can cause easy bruising, bleeding gums, and internal bleeding.

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What triggers ITP?

Immune thrombocytopenia usually happens when your immune system mistakenly attacks and destroys platelets, which are cell fragments that help blood clot. In adults, this may be triggered by infection with HIV , hepatitis or H. pylori — the type of bacteria that causes stomach ulcers.

Can ITP turn into leukemia?

ITP does not turn into a more serious blood disorder, like leukemia or aplastic anemia. It is usually not a sign that their child will later develop other autoimmune conditions, such as systemic lupus erythematosus (SLE or “lupus”).

How long can you live with TTP?

In the authors' series of 126 patients, the estimated 10-year survival rate of patients without comorbid conditions was 82%, compared with a survival rate of 50% if comorbid conditions were present.

What is the survival rate of TTP?

Untreated, TTP has a mortality rate of as high as 90%. With plasma exchange, the mortality rate is reduced to 10-20%.

How common is TTP?

Thrombotic Thrombocytopenic Purpura is a rare blood disorder that is considered a true medical emergency. TTP is diagnosed at a rate of 3-4in 1 million people per year. Potentially fatal complications can result from internal blood clotting, with damage to critical organs such as the brain and heart.

What drugs can cause TTP?

Drugs such as mitomycin, cyclosporine, cisplatin, bleomycin, quinine, and ticlopidine have been associated with HUS and TTP.

Is TTP curable?

Can TTP Be Cured? About 80% of patients will survive. The majority of patients will have only one episode of TTP; few will have relapses.

Is TTP an emergency?

Thrombotic thrombocytopenic purpura (TTP) is a medical emergency that is almost always fatal if appropriate treatment is not promptly initiated. (Thromb Res. 2020;193:53.) Acquired TTP usually presents as severe microangiopathic hemolytic anemia (MAHA) and thrombocytopenia in a previously healthy individual.

Can ITP be caused by stress?

Research suggests that physical or psychological stress and the resultant oxidative stress in the body may also trigger episodes of ITP,7 exacerbate fatigue15 and prolong duration of the platelet disorder in children.

What is a TTP episode?

Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder. Key points. TTP is a serious, ultra rare and potentially life-threatening condition. 30%-50% of patients will experience multiple episodes of TTP (called relapses) after their initial diagnosis.

Can TTP cause strokes?

Ischaemic stroke has been reported as a consequence of TTP. However, strokes due to a large cerebral artery occlusion (LCAO) are rare in patients with TTP.

Can TTP be hereditary?

Hereditary TTP, caused by pathogenic variants in the ADAMTS13 gene, is much less common but no less life-threatening. Individuals with hereditary TTP require life-long care and special attention during certain life-stages, especially in the neonatal period and during pregnancy.

Is TTP a disability?

In order for chronic thrombocytopenia to be considered disabling for Social Security Disability purposes, it must be severe.

When is TTP diagnosed?

A normal platelet count is between 150,000 and 450,000 per microliter of blood. If someone has a platelet count lower than 100,000 per microliter of blood with no other reason for low platelets, they are considered to have ITP.